"And unlike peptides, they're not rapidly degraded by enzymes, so they could be used at a much lower dose." "Peptoids are easy to make," says Barron, who is at Stanford University. Instead, she and her colleagues emulated the key biophysical attributes of LL-37 in smaller, more stable molecules called peptoids. In the body, antimicrobial peptides such as LL-37 help keep viruses, bacteria, fungi, cancer cells and even parasites under control."Īnnelise Barron, Ph.D., Project's Principal Investigatorīut peptides are quickly cleared by enzymes, so they're not ideal drug candidates. The meeting features more than 7,000 presentations on a wide range of science topics. 22-26, and on-demand content will be available Aug. ACS Fall 2021 is a hybrid meeting being held virtually and in-person Aug. The researchers will present their results at the fall meeting of the American Chemical Society (ACS). These small synthetic molecules could one day cure or prevent many kinds of infections, including COVID-19.
Today, scientists report success in using mimics known as peptoids to treat animals with herpes virus infections. Synthetic peptides could reinforce this defense but don't last long in the body, so researchers are developing stable peptide mimics.
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